New Breakthrough, Special Diet Can Help The Most Deadly Brain Cancer

JAKARTA – A recent study published in the journal Nature on September 3 found that changes in certain diets can make brain cancer deadly, glioblastoma, easier to treat. This study shows that low-serin diets can increase the effectiveness of chemoradiation (coupling chemotherapy and radiotherapy) as well as prolong life expectancy in experimental mice.

Glioblastoma is the most aggressive type of brain cancer with a high level of recurrence and a limited therapeutic response. One of the main challenges is the ability of cancer cells to change their metabolism to continue to reproduce.

“The real art of therapy is how to make it kill far more cancer cells than normal cells,” said Costas Lyssiotis, University of Michigan’s oncology professor, quoted from the Live Science page.

In this study, the research team led by Dr. And Wahl from the University of Michigan studied how glioblastoma utilizes glucose differently from healthy cells.

Normal brain cells use glucose to produce energy through respiration and produce serin, an amino acid important for brain function.

tumour cells actually direct glucose to produce nucleotides, the basic ingredients of DNA that allow them to repair damage and divide non-stop.

Sel cancer juga mengambil serin dari jaringan sekitar untuk semakin memperkuat pertumbuhannya.

Seeing this gap, researchers tried to give mice a low-serin diet. As a result, cancer cells are forced to divert glucose back to serin production, thereby reducing their ability to produce nucleotides. As a result, cancer cells become more susceptible to chemoradiation.

Those who are given a combination of low-series diet and live longer chemoradiation than those who only get chemoradiation, the researchers wrote.

Although preliminary results are promising, experts emphasize that glioblastoma cells are very adaptive. There is a possibility that cancer will find new ways to survive.

If you can find that weak point, reduce the serin, then attack with therapy, you can hit them before finding a way out, “said Lyssiotis.

Dr. Wahl added that further clinical trials in humans are being prepared. However, he acknowledged the challenges in asking patients to undergo chemotherapy, radiotherapy as well as a special diet.

“We look forward to bringing these findings to patients later this year or early next year.” Wahl said.

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