The 8 Best Dietitian-Approved Nitric Oxide-Boosting Supplements of 2025
Type Zero Clean Stim-Free Preworkout + Nitric Oxide booster is our pick for the best powder nitric oxide booster, for several reasons. We like that unlike many powdered pre-workout/nitric oxide boosters, this one doesn’t contain any stimulants, such as caffeine. Since it’s not recommended that you consume caffeine close to bedtime, this powder can be used regardless of when you usually work out.
This supplement also contains both L-citrulline and arginine alpha-ketoglutarate (AKG), which is L-arginine that’s bonded with alpha-ketoglutarate, which can also support energy metabolism.
Research shows that L-citrulline is better for promoting NO synthesis, as L-arginine is not well-absorbed in the intestines. In contrast, L-citrulline is well-tolerated and well-absorbed, making it ideal for stimulating NO production.
For improving athletic performance, some benefits have been shown when taking doses of 6,000 to 8,000 mg of a combination of L-citrulline and malic acid around one hour before exercise.
Most supplements that are third-party tested don’t contain this much, but this supplement comes close, at 5,000 mg of citrulline. It’s available in four different flavors (fruit punch, cherry limeade, pineapple orange mango, and blackberry lemonade), so there’s something for everyone to enjoy.
This supplement also contains beetroot powder. Beets contain nitrates, which stimulate NO production and may improve athletic performance.
Type Zero also contains ingredients like chromium, gamma-aminobutyric acid (GABA), and beta-alanine. Chromium has been shown to significantly reduce fasting blood sugar and insulin levels in people with type 2 diabetes, while GABA supplementation may help protect the brain, reduce insomnia, and lower blood pressure.
According to the International Society of Sports Nutrition, beta-alanine supplementation may help improve exercise performance and reduce muscle fatigue.
However, it may cause a tingling sensation in some people. This can be avoided by taking a lower dose (1.6 grams) or choosing a sustained-release supplement. Since this supplement only contains 400 milligrams of beta-alanine, it’s less likely to cause a tingling sensation.
This supplement is third-party tested and manufactured in a CGMP-compliant facility, ensuring that you receive a high-quality supplement.
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